Tom3 schreef op 13 juni 2021 11:41:
Via Adam May het volgende gezien op Twitter:twitter.com/physorg_com/status/138158...
In their study, published in PNAS, Crick scientists retrospectively analyzed data from previous research where they had been studying the role of the OCT4 protein in human embryos during the first few days of development.
The team found that while the majority of CRISPR-Cas9-induced mutations were small insertions or deletions, in approximately 16% of samples there were large unintended mutations that would have been missed by conventional methods to assess DNA changes.
Research is ongoing to understand the exact nature of the changes at the target sites but this could include deletions of sections of DNA or more complex genomic rearrangements.