En het antwoord op vragen van de Vertex aanhangere Geof Porges:
So regarding the first part of your question, the thromboembolic event rates with baracitinib, the most recent data that we have shown was a presentation at ACR late last year by Mark Genovese, which is an oral presentation. Now this is just from the DARWIN 1, 2, and 3 extension studies, where we have about 1,700 patient years of exposure, but that rate was very low, only one patient in that presentation who had both a DVT and a PE. So the rate actually in that presentation was 0.06 per 100 patient years. But, Geoff, so far we've got thousands of patients in Phase 3. We've got a relatively small data set in terms of exposure, but that's what we have said so far. We continue to collect all of that information.
The other point to raise about this was the discussion recently at the Advisory Committee and whether this is slightly or partly related to JAK-2. As you know, filgotinib is very selective for JAK-1. And in terms of JAK-2 specificity, we don't have that at all. So we don't see any changes in hemoglobin. When we see positive changes in hemoglobin, we don't see any increase in platelets. In fact, we see a small decrease in platelets. Whether or not that's related to thromboembolic phenomena, we don't know.
And then I believe our fledgling programs that are now developing in full force in inflammation, with filgotinib in multiple diseases are becoming differentiated, exciting, and heading in the right direction, particularly with things such as the Verily collaboration.