En ook diabetes:
XOMA 052 Demonstrates Anti-Inflammatory Effects in Diabetes Animal Studies; Data Presented At ADA
SAN FRANCISCO, Jun 7, 2008 (PrimeNewswire via COMTEX News Network) -- XOMA Ltd. (Nasdaq:XOMA) announced today at the American Diabetes Association's 68th Scientific Sessions that a study of XOMA 052, a potent anti-inflammatory drug candidate, preserved insulin production, reduced fasting glucose and cholesterol levels and preserved beta-cell function in mice with a diet-induced obesity model of Type 2 diabetes.
"The animal data indicate that XOMA 052 may be the first disease-modifying anti-diabetic therapy with the potential to improve glycemic control and address the risk of cardiovascular events," noted Alan Solinger, MD, XOMA's Vice President of Clinical Immunology. "Whereas most current therapies for Type 2 diabetes increase insulin production or peripheral insulin sensitivity, this approach offers the potential to normalize beta-cell function and prevent future damage to the beta-cells that generate insulin -- a disease modifying effect."
A poster detailing the data, titled "XOMA 052, an Anti-IL-1 beta Antibody, Preserves Beta-Cell Function and Reduces Hyperglycemia in the Diet-Induced Obesity Model of Type 2 Diabetes," is being presented at the Scientific Sessions on June 9, 2008 at 12:00 p.m. Pacific time.
Study Findings
In the 14-week study, mice were fed either a normal diet or a high-fat, high-sucrose diet. Subsets were then treated with either twice weekly injections of XOMA 052 (1 mg/kg) or a negative control antibody.
After 14 weeks, the mice treated with XOMA 052 showed:
* Statistically significant preservation of insulin production
during glucose tolerance testing;
* Statistically significant reduction in glucose levels;
* Statistically significant reduction in cholesterol levels
The animal study also included a positive control group that received IL-1Ra, or anakinra. IL-1Ra is a recombinant IL-1 receptor antagonist that blocks the receptor signals from both IL-1 alpha and IL-1 beta. Unlike IL-1Ra, XOMA 052 is designed to specifically block only IL-1 beta. Results showed that blocking IL-1 beta alone was sufficient to preserve beta cell function.
XOMA 052 and Type 2 Diabetes
In April 2007, a clinical study published in the New England Journal of Medicine demonstrated proof of concept of IL-1 blockade in Type 2 diabetes. In the study, administration of anakinra, an IL-1 receptor blocker or antagonist, to Type 2 diabetes patients resulted in statistically significant improvement in the control of blood glucose, improvement in beta-cell secretory function and reduction of systemic inflammation.
Earlier preclinical data have shown that IL-1 beta plays a role in glucose-induced beta-cell apoptosis and dysfunction and that IL-1Ra treatment prevents hyperglycemia by improving glucose tolerance and insulin secretion in a mouse model of Type 2 diabetes.
About XOMA 052
XOMA 052 is a potent monoclonal antibody with the potential to improve the treatment of patients with a wide variety of inflammatory diseases. XOMA 052 binds strongly to interleukin-1 beta (IL-1 beta), a pro-inflammatory cytokine that is involved in the development of diabetes, rheumatoid arthritis, gout, and other diseases. By binding IL-1 beta, the drug blocks the activation of the IL-1 receptor, thereby preventing the cellular signaling events that produce inflammation. XOMA 052 is a humanized IgG2 antibody with an expected half-life of 15 to 21 days. Based on its binding properties, specificity to IL-1 beta and half-life, XOMA 052 may provide convenient dosing of once per month or every two months.
XOMA 052 is currently being developed for acute, chronic and orphan indications, including its evaluation in two Phase 1 clinical studies in Type 2 diabetes. XOMA 052 could prove to be a disease-modifying therapy for diabetes by addressing inflammation as an underlying cause of the epidemic disease, whereas current therapies focus almost exclusively on improving the body's ability to produce and respond to insulin.
The two randomized, placebo-controlled, double-blind Phase 1 studies of XOMA 052 in Type 2 diabetes are designed to assess safety and pharmacokinetics, and include measures of systemic inflammation, Hemoglobin A1c and other diabetes readings. Each study, one in Europe and one in the U.S., will enroll up to 36 patients in six cohorts and involves single-dose intravenous administration and dose-escalation by cohort. The U.S. study includes two additional parts that will investigate single-dose subcutaneous and multi-dose intravenous administration in up to 36 additional patients.
In 2008, XOMA plans to initiate clinical studies of XOMA 052 in rheumatoid arthritis, acute gout, and systemic juvenile idiopathic arthritis (sJIA).
The central role of the IL-1 pathway in multiple diseases has been clinically validated by several inhibitors of the IL-1 pathway in development and by two FDA approved therapies based on IL-1 blockade. These disease indications include rheumatoid arthritis, systemic juvenile idiopathic arthritis, gout, Muckle-Wells syndrome and others.
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